Suda51: No More Heroes on Wii because of controller

“One of the main reasons why we’re back on Wii is because of the controller. When we released the first one on Wii, you had this feeling just finished with moving the controller; it was really good. So, if we released it on Xbox 360, for example, we’d have to rethink this feeling. I wanted to keep the game’s controller gimmick, so that’s why the fighting was more fitting on Wii, rather than on other platforms.” – Suda51

Source 1, Source 2