Lifetime NPD software sales – revenue ranked

1. Guitar Hero III: Legends of Rock* $830.9 million
2. Call of Duty: Black Ops $787.4 million
3. Wii Fit (w/ Balance Board) $736.6 million
4. Call of Duty: Modern Warfare 2 $713.6 million
5. Rock Band*$670.7 million
6. Wii Play (w/ Wii Remote)
7. Guitar Hero World Tour*
8. Wii Fit Plus*
9. Mario Kart Wii (w/ Wii Wheel)
10. Call of Duty 4: Modern Warfare

Items marked with a star indicates total sales for the product. In other words, the rankings above take bundled sales into consideration, such as the Wii Fit title and its Balance Board bundle.

Source